Thermo Fisher Scientific PTGDS Polyclonal Antibody
Human PTGDS 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 IHC(P) 실험에 적합함. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. PBS 기반 보존액에 40% glycerol 포함, 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PTGDS. Recombinant protein control fragment (Product #RP-88648). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2646107 |
Product Specific Information
Immunogen sequence:
SWLREKKAAL SMCKSVVAPA TDGGLNLTST FLRKNQCETR TMLLQPAGSL GSYSYRSPHW GSTYSVSVVE TDYDQYALLY SQGSKGPGED FRMATLYSRT QT
Highest antigen sequence identity to the following orthologs:
- Mouse: 76%
- Rat: 74%
Target Information
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to prostaglandin D2 (PGD2). PGD2 functions as a neuromodulator and trophic factor in the central nervous system. It is involved in smooth muscle contraction/relaxation and inhibits platelet aggregation.
PTGDS also contributes to the maintenance of several physiological barriers (blood-brain, blood-retina, blood-aqueous humor, blood-testis). Overexpression studies suggest involvement in regulation of non-rapid eye movement (NREM) sleep.
PTGDS is the most abundant protein in cerebrospinal fluid and may act as a Beta-Amyloid chaperone, potentially influencing plaque deposition in Alzheimer’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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