Thermo Fisher Scientific E-cadherin Monoclonal Antibody (DH01 (DCS-266))

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA5-11496 targets APC/C activator protein CDH1 in IP, ICC/IF, and WB applications and shows reactivity with human samples.
The MA5-11496 immunogen is recombinant human cdh1 protein.

Target Information

E-Cadherin (epithelial cadherin) is a classical cadherin from the calcium-dependent adhesion protein superfamily. It is a cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail.
Mutations in this gene are associated with gastric, breast, colorectal, thyroid, and ovarian cancers. Loss of function contributes to cancer progression by increasing proliferation, invasion, and metastasis.
E-cadherin mediates bacterial adhesion to mammalian cells and is required for internalization. It plays a central role in tissue architecture and integrity.
In humans, E-cadherin is encoded by the CDH1 gene on chromosome 16. Reduced or lost E-cadherin expression correlates with increased tumor invasiveness and metastatic potential.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.