Thermo Fisher Scientific Cathepsin K Polyclonal Antibody
Cathepsin K 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, Flow Cytometry에 사용 가능. 인간 및 생쥐 반응성. Protein A 및 항원 친화 크로마토그래피로 정제. 골 재형성 및 종양 침윤 연구에 적합.
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 | - |
| Flow Cytometry (Flow) | 1:10–1:50 | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 207–237 of human Cathepsin K (CTSK) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2087668 |
Product Specific Information
This antibody is predicted to react with bovine, porcine, non-human primate, and rabbit based on sequence homology.
Target Information
The Cathepsin K protein is a lysosomal cysteine protease involved in bone remodeling and resorption. It belongs to the peptidase C1 family and is predominantly expressed in osteoclasts. The protein is also expressed in a significant fraction of human breast cancers, potentially contributing to tumor invasiveness. Mutations in this gene cause pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may also be subject to RNA editing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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