
Thermo Fisher Scientific Hif3 alpha Polyclonal Antibody
HIF3 alpha 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체입니다. Western blot에 적합하며 인간 시료에 반응합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 완충액에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human HIF3 alpha. The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.48 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901961 |
Product Specific Information
- Centrifuge briefly prior to opening.
Target Information
Cell growth and viability are compromised by oxygen deprivation (hypoxia). Hypoxia-inducible factors, including HIF-1 alpha, HIF-1 beta (Arnt 1), EPAS-1 (HIF-2 alpha), and HIF-3 alpha, induce glycolysis, erythropoiesis, and angiogenesis to restore oxygen homeostasis.
These factors belong to the Per-Arnt-Sim (PAS) domain transcription factor family.
In response to hypoxia, HIF-1 alpha is upregulated and forms a heterodimer with Arnt 1 to create the HIF-1 complex, which binds to the hypoxia responsive element (HRE) of hypoxia-inducible genes, activating transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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