Thermo Fisher Scientific CRP Monoclonal Antibody (P4D7)
Thermo Fisher Scientific의 CRP Monoclonal Antibody (P4D7)는 인간 C-반응성 단백질(CRP)을 검출하기 위한 마우스 IgG2a 단일클론 항체입니다. ELISA, IP, RIA, ICC/IF 등 다양한 응용에 적합하며, 고순도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
| Radioimmune Assays (RIA) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | P4D7 |
| Immunogen | Purified human plasma CRP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Ion-exchange chromatography |
| Storage Buffer | PBS, pH 7.4, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Refrigerate at 2–8°C for up to 6 months; long-term storage at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10982599 |
Product Specific Information
- MA5-14744 targets C Reactive Protein (CRP) in ELISA, IP, and RIA applications and shows reactivity with human samples.
- The immunogen is purified human plasma CRP.
- Detects CRP with a predicted molecular weight of approximately 23 kDa.
- Product MA514744 is a smaller package size of MIC0501 (formerly sold as a Seradyn product).
Target Information
CRP (C-reactive protein) is a major cyclic, pentameric acute-phase protein composed of five identical, noncovalently bound, nonglycosylated subunits. Each subunit consists of 206 amino acids with a molecular weight of approximately 24 kDa. It is produced by the liver, and plasma levels rise dramatically during inflammatory processes.
CRP initiates the classical complement cascade, binds to nuclear components (chromatin, histones, etc.), and plays a key role in innate immunity. It mediates pre-immune nonspecific host resistance and can increase 100–1000 fold in response to injury, infection, or inflammation.
CRP acts as an opsonin, activates monocytes/macrophages, and binds to chromatin, histones, and snRNP, suggesting a scavenger role during cell necrosis. Elevated basal CRP levels are associated with increased risk of hypertension and cardiovascular disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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