Thermo Fisher Scientific CHGA Monoclonal Antibody (UMAB109), UltraMAB

Applications

• Western Blot (WB): Assay-dependent
• Immunohistochemistry (Paraffin) (IHC (P)): 1:200

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Chromogranin A (CHGA) belongs to the chromogranin/secretogranin family of neuroendocrine secretory proteins.
It is localized in secretory vesicles of neurons and endocrine cells and serves as a precursor to three biologically active peptides: vasostatin, pancreastatin, and parastatin.
These peptides function as autocrine or paracrine negative modulators of the neuroendocrine system.
CHGA is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors.
Coexpression of chromogranin A and neuron-specific enolase (NSE) is common in neuroendocrine neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.