Thermo Fisher Scientific BDNF Polyclonal Antibody
BDNF 단백질을 인식하는 Thermo Fisher Scientific의 sheep polyclonal 항체로, WB 및 IHC에 적합합니다. 인간, 마우스, 원숭이, 랫트에 반응하며, 높은 특이성과 안정성을 제공합니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific BDNF Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–5 µg/mL | - |
| Immunohistochemistry (IHC) | 1–5 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human mature BDNF conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- The peptide is homologous in many other species including rat, mouse, zebrafish, and xenopus.
- Specificity: mature BDNF.
Target Information
BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. It is synthesized as pre-proBDNF, followed by cleavage to proBDNF, and further processed to the mature 14 kDa protein. Both mature and pro-BDNF are biologically active and secreted in synaptic vesicles.
BDNF is widely expressed in the central nervous system and acts via TrkB and p75-NTR receptors to promote neuronal survival, differentiation, and synaptic regulation. It plays a key role in memory formation and is essential for the survival of striatal neurons.
Reduced BDNF expression has been observed in Alzheimer’s and Huntington’s disease and may be involved in stress response and mood regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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