Thermo Fisher Scientific TGM2 Monoclonal Antibody (OTI4H5), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Transglutaminase (TGase) catalyzes protein crosslinking by forming ε-(γ-glutamyl) lysine isopeptide bonds and requires Ca²⁺ binding for activity.
In mammals, eight distinct TGase isoenzymes are identified. Tissue transglutaminase (tTGase or TGase 2) consists of four domains: an N-terminal β-sandwich, a catalytic core, and two C-terminal β-barrel domains.
tTGase is implicated in cell death, proliferation, differentiation, and receptor-mediated endocytosis. In Alzheimer’s disease, elevated tTGase activity leads to polymerization of proteins such as Aβ peptide, β-amyloid precursor protein, and tau, contributing to neurofibrillary tangle formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.