Thermo Fisher Scientific CPA6 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 130-437 of human CPA6 (NP_0650943) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CPA6,uniProtId:Q8N4T0-1,ncbiNodeId:9606,antigenRange:130-437,antigenLength:437,antigenImageFileName:PA5-89343_CPA6_Q8N4T0-1_Rabbit.svg,antigenImageFileNamePDP:PA5-89343_CPA6_Q8N4T0-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.31 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805506

Product Specific Information

Immunogen sequence: SLSGYNYEVY HSLEEIQNWM HHLNKTHSGL IHMFSIGRSY EGRSLFILKL GRRSRLKRAV WIDCGIHARE WIGPAFCQWF VKEALLTYKS DPAMRKMLNH LYFYIMPVFN VDGYHFSWTN DRFWRKTRSR NSRFRCRGVD ANRNWKVKWC DEGASMHPCD DTYCGPFPES EPEVKAVANF LRKHRKHIRA YLSFHAYAQM LLYPYSYKYA TIPNFRCVES AAYKAVNALQ SVYGVRYRYG PASTTLYVSS GSSMDWAYKN GIPYAFAFEL RDTGYFGFLL PEMLIKPTCT ETMLAVKNIT MHLLKKCP; Positive Samples: HT-29, HepG2, HeLa; Cellular Location: extracellular matrix, extracellular space

Target Information

Members of the M14 metallocarboxypeptidase protein family serve many diverse functions and are divided into three subfamilies based on structure, function and amino acid sequence similarity. As a member of the A/B subfamily, CPA6 (Carboxypeptidase A6) is a 437 amino acid secreted, zinc-binding protein that contains a characteristic propetide at the amino terminus, which is cleaved off upon enzyme activation. Although expressed broadly in embryonic tissues, CPA6 is found at highest levels in the adult olfactory bulb and epididymus. CPA6 functions to cleave large C-terminal hydrophobic residues off of proteins and protein substrates and is likely involved in the extracellular processing of neuropeptides. Mutations in the gene encoding CPA6 have been linked to Duane syndrome, a congential eye-movement disorder characterized by the abnormal development of cranial nerve VI (the abducens nerve). There are three isoforms of CPA6 that exist as a result of alternative splicing events.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.