Thermo Fisher Scientific ST2 Polyclonal Antibody

Thermo Fisher Scientific ST2 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: Raw264.7, Rat colon
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

IL-33R, also known as ST2, is a receptor for IL-33 and a member of the IL-1 receptor family of innate receptors. Its extracellular domain consists of three Ig-like domains that directly interact with its co-receptor IL-1RAcP and the ligand alarmin IL-33.
IL-33 binding leads to association of the IL-33R complex with adaptor proteins MyD88, IRAK1, IRAK4, and TRAF6, activating NF-κB and MAPK pathways. This triggers the release of chemokines and cytokines such as IL-5, IL-6, IL-8, and IL-13.
Two common isoforms result from alternative splicing: ST2L (membrane-bound) and ST2S (soluble). The soluble form acts as a decoy to dampen IL-33 signaling. IL-33R is primarily expressed by mast cells, basophils, and eosinophils, and in mice, also by ILC2 and Th2 cells. IL-33R signaling is implicated in immune conditions including allergies, arthritis, atherosclerosis, and sepsis.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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