Thermo Fisher Scientific Phospho-TAK1 (Thr187) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

TAK1 (also known as MAP3K7) is a serine/threonine kinase involved in multiple signaling pathways. Initially identified as a TGF-β-activated kinase, TAK1 interacts with TGF-β receptor and TRAF6 to modulate activation of JNK and p38. It also participates in Wnt, BMP, and activin signaling, as well as responses to thyroid hormone, osmotic stress, endothelin, and ephrine.

Through activation of von Hippel-Lindau tumor suppressor expression, TAK1 represses PDGF-B, integrin β1, and integrin β5, facilitating proper wound healing. TAK1 is essential for IKK activation in pathways including IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I. Activation of the TAK1-IKK pathway requires TAB2/3 and ubiquitination, during which TAK1 is autophosphorylated at Thr178, Thr184, Thr187, and Ser192 before phosphorylating IKK-β. TAK1 also represses human telomerase reverse transcriptase, indicating a role in regulating cell lifespan.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.