Thermo Fisher Scientific HSPA4 Polyclonal Antibody
Thermo Fisher Scientific의 HSPA4 Polyclonal Antibody는 인간, 마우스, 랫트에 반응하며 Western blot 및 ICC/IF에 적합합니다. 합성 펩타이드 항원을 기반으로 한 rabbit IgG 항체로, 1 mg/mL 농도의 액상 형태입니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human HSPA4 (Accession P34932), corresponding to amino acid residues E767–A817 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853725 |
Product Specific Information
This antibody detects endogenous levels of total HSP74.
Target Information
The HSP70 family is composed of four highly conserved proteins: HSP70, HSC70, GRP75, and GRP78.
HSP70 expression is strongly induced in response to heat stress.
HSP70 and HSC70 play key roles in the cytosolic, endoplasmic reticulum, and mitochondrial import machinery and are found in both the cytosol and nucleus of mammalian cells.
GRP78 is localized in the endoplasmic reticulum, where it receives imported secretory proteins and assists in folding and translocation of nascent peptide chains.
GRP75 is restricted to the mitochondrial matrix and aids in the translocation and folding of nascent polypeptide chains of both nuclear and mitochondrial origin.
Members of the HSP70 family act as force-generating motors, relying on ATP hydrolysis for their activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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