Thermo Fisher Scientific CD101 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

• Purity is >95% by SDS-PAGE.

Target Information

CD101, also known as V7 antigen, is a member of the immunoglobulin superfamily. It exists as a disulfide-linked homodimer with an unknown function. CD101 is expressed on monocytes, granulocytes, and dendritic cells (Langerhans-like cells expressing HLA-DR, CD1a, CD1c).
Expression on T lymphocytes is important for cell activation. CD101⁺CD28⁺ cells are highly responsive to CD28 signaling. In combination with anti-CD28 or suboptimal levels of anti-CD3, anti-CD101 can increase proliferation, suggesting an activating role.
The monoclonal antibody BB27 has been shown to inhibit T-cell reactivity in allogeneic and antigen-specific mixed DC–T cell cultures.
Recent studies demonstrated that mouse CD101 is expressed on a subpopulation of regulatory T cells (CD4⁺, CD25⁺, Foxp3⁺) with high suppressor activity. Expression of CD101 on human PBMCs shows staining of about 30% of Foxp3⁺ cells, though higher suppressor activity in the human CD101 population has not been confirmed.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.