Thermo Fisher Scientific RFWD3 Polyclonal Antibody
Thermo Fisher Scientific RFWD3 Polyclonal Antibody는 인간 RFWD3 단백질을 인식하는 토끼 유래 다클론 항체입니다. Western blot에 적합하며, DNA 손상 복구 연구에 활용됩니다. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to a region within amino acids 515–763 of Human RFWD3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.96 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2548141 |
Product Specific Information
- Recommended positive controls: NT2D1, IMR32, MCF-7
- Predicted reactivity: Human (99%)
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage. Plays a key role in RPA-mediated DNA damage signaling and repair by mediating ubiquitination of the RPA complex (RPA1, RPA2, RPA3) and RAD51 at stalled replication forks, promoting homologous recombination.
Also mediates ubiquitination of p53/TP53 in the late response to DNA damage, acting as a positive regulator of p53 stability and the G1/S DNA damage checkpoint.
In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53.
[Source: UniProt]
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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