Thermo Fisher Scientific Cullin 5 Monoclonal Antibody (ZC009)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-2 µg/mL

-

ELISA (ELISA)

Assay-dependent

-

Product Specifications

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

ZC009

Immunogen

Synthetic peptide derived from the N-terminal region of the mouse and rat CUL-5/VACM-1 proteins, which are 89% homologous to human if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Cullin 5,uniProtId:Q9JJ31-1,ncbiNodeId:10114,antigenRange:1,antigenLength:780,antigenImageFileName:39-9000_Cullin_5_Q9JJ31-1_House_mouse.svg,antigenImageFileNamePDP:39-9000_Cullin_5_Q9JJ31-1_House_mouse_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2533440

Target Information

CUL5 is a core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. It seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein and may form a cell surface vasopressin receptor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.