Thermo Fisher Scientific ZNF304 Polyclonal Antibody
Human ZNF304 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC 및 ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공됩니다. 유전자 발현 조절 및 암 관련 연구용으로 사용됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ZNF304. Recombinant protein control fragment (Product #RP-101284). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2650056 |
Product Specific Information
- Immunogen sequence: SLRQHQGDYD GQMLFSCGDE GKAFLDTFTL LDSQMTHAEV RPFRCLPCGN VFKEKS
- Highest antigen sequence identity to orthologs: Mouse – 43%, Rat – 43%
Target Information
ZNF304 acts as a transcriptional regulator and plays a role in gene silencing. It forms a corepressor complex required for KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer cells.
It maintains a transcriptionally repressive state in undifferentiated embryonic stem cells by inducing H3K27me3 via Polycomb group complexes.
ZNF304 associates with promoter regions of TSGs and recruits TRIM28, DNMT1, SETDB1, and PcG complexes.
It is involved in metastatic processes, promoting cell migration, proliferation, and resistance to anoikis in ovarian carcinoma cells through integrin-mediated signaling.
ZNF304 also positively regulates beta-1 integrin transcription and promotes angiogenesis and tumor growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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