Thermo Fisher Scientific LIMP2 Polyclonal Antibody, Biotin
LIMP2 단백질을 인식하는 염소 유래 Biotin 결합 폴리클로날 항체. Western blot 및 IHC에 사용 가능하며, 인간 시료에 반응. 0.5 mg/mL 농도의 액상 형태로 제공되며, TBS(pH 7.3)와 0.5% BSA 포함. -20°C에서 보관.
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- PA5142468
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–3 µg/mL |
| Immunohistochemistry (IHC) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-NKANIQFGDNGTTIS |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2933116 |
Product Specific Information
- Expected to recognize isoform 1 (NP_005497.1) only.
- Tested in Peptide ELISA: antibody detection limit dilution 1:4,000.
Target Information
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism, and their plasma concentrations are inversely correlated with the risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are alternatively spliced products of a single gene.
SR-BII differs from SR-BI in that the encoded C-terminal cytoplasmic domain is almost completely different. SR-BII binds HDLs and mediates selective uptake of HDL cholesteryl ester, but with approximately 4-fold lower efficiency than SR-BI.
Nuclease protection assays show SR-BII to be abundant in mouse tissues expressing SR-BI, with SR-BII expression found in liver, adrenal glands, and testes. Although the role of SR-BII is not completely clear, research suggests that it may be a functional HDL receptor. In addition, SR-BII mRNA results from alternative splicing of SR-BI precursor transcripts, with the SR-BII isoform mediating selective transfer of lipid between HDL and cells.
The relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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