Thermo Fisher Scientific LIMP2 Polyclonal Antibody, Biotin

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Expected to recognize isoform 1 (NP_005497.1) only.
• Tested in Peptide ELISA: antibody detection limit dilution 1:4,000.

Target Information

High density lipoproteins (HDLs) play a critical role in cholesterol metabolism, and their plasma concentrations are inversely correlated with the risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are alternatively spliced products of a single gene.
SR-BII differs from SR-BI in that the encoded C-terminal cytoplasmic domain is almost completely different. SR-BII binds HDLs and mediates selective uptake of HDL cholesteryl ester, but with approximately 4-fold lower efficiency than SR-BI.

Nuclease protection assays show SR-BII to be abundant in mouse tissues expressing SR-BI, with SR-BII expression found in liver, adrenal glands, and testes. Although the role of SR-BII is not completely clear, research suggests that it may be a functional HDL receptor. In addition, SR-BII mRNA results from alternative splicing of SR-BI precursor transcripts, with the SR-BII isoform mediating selective transfer of lipid between HDL and cells.

The relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.