Thermo Fisher Scientific HERPUD1 Polyclonal Antibody
HERPUD1 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체로, Western blot과 IHC(P)에서 사용 가능. 인간 시료에 반응하며, ER 스트레스 및 단백질 분해 연구에 적합. 고순도 친화 크로마토그래피 정제 및 안정한 PBS/glycerol 저장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human HERPUD1 (Accession Q15011), corresponding to amino acid residues M1–P46 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2815628 |
Product Specific Information
Antibody detects endogenous levels of total HERP.
Target Information
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This includes inhibition of translation to prevent further accumulation of unfolded proteins, increased expression of folding-related proteins (UPR), and degradation of misfolded proteins by the ER-associated degradation (ERAD) system.
HERPUD1 may play a role in both UPR and ERAD. Its expression is induced by UPR, and it contains an ER stress response element in its promoter region. The encoded protein has an N-terminal ubiquitin-like domain that may interact with the ERAD system. HERPUD1 has been shown to interact with presenilin proteins and increase amyloid-beta levels upon overexpression.
Alternative splicing produces multiple transcript variants, though the full-length nature of all variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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