Thermo Fisher Scientific RBP3 Polyclonal Antibody

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) (IHC (P)): 1:500–1:1,000

Product Specifications

Product Specific Information

Immunogen sequence:
GVEPDITVPMS EALSIAQDIV ALRAKVPTVL QTAGKLVADN YASAELGAKM ATKLSGLQSR YSRVTSEVAL AEILGADLQM LSGDPHLKAA HIPENAKDR

• Highest antigen sequence identity to the following orthologs:
  • Mouse: 90%
  • Rat: 92%

Target Information

Interphotoreceptor retinol-binding protein (IRBP) is a large glycoprotein known to bind retinoids and is found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and photoreceptor cells.
It is thought to transport retinoids between these layers, playing a critical role in the visual process.

The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns (1.6–1.9 kbp each).
It is transcribed by photoreceptor and retinoblastoma cells into ~4.3-kb mRNA, which is translated into a glycosylated protein of 135 kDa.
The amino acid sequence can be divided into four contiguous homology domains (33–38% identity), suggesting gene duplication events.
The first three domains and part of the fourth are encoded by the first large exon (3,180 bp), and the remainder by the last three exons (191, 143, and ~740 bp).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.