
Thermo Fisher Scientific IL-10 Monoclonal Antibody (945A1A926C2), Biotin
돼지 IL-10 단백질을 인식하는 Mouse IgG1 단일클론 항체로 Biotin 결합형. Flow Cytometry, ELISA, Luminex 등 다양한 면역분석에 사용 가능. 고순도 정제, 안정적인 PBS buffer 보존. 연구용으로 면역조절 관련 실험에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | - | View 2 publications |
| ELISA | Assay-dependent | View 2 publications |
| Luminex (LUM) | - | View 2 publications |
| Affinity Purification (AP) | - | View 1 publication |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Pig |
| Published Species | Pig |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 945A1A926C2 |
| Immunogen | Recombinant swine IL-10 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2536428 |
Target Information
IL-10 encodes a cytokine primarily produced by monocytes and lymphocytes. It plays a crucial role in immunoregulation and inflammation by down-regulating Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. IL-10 enhances B cell survival, proliferation, and antibody production, and can inhibit NF-kappa B activity. It is involved in the JAK-STAT signaling pathway. Knockout studies indicate IL-10 is essential for intestinal immune regulation. Mutations are associated with increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases linked to IL-10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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