Thermo Fisher Scientific USP7 Monoclonal Antibody (2A1C6)
USP7 단백질을 인식하는 Mouse IgG2b 단일클론 항체로, Western blot, IHC, ICC/IF, Flow cytometry, ELISA 등 다양한 응용에 사용 가능. 인간, 생쥐, 설치류 등 반응. Protein G 정제, 1 mg/mL 농도, PBS buffer 및 sodium azide 포함.
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Thermo Fisher Scientific USP7 Monoclonal Antibody (2A1C6)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2A1C6 |
| Immunogen | Purified recombinant fragment of human USP7 (AA: 1–208) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3093976 |
Target Information
USP7 (also known as HAUSP) is a ubiquitin-specific protease that removes ubiquitin from substrate proteins. It plays a key role in regulating protein stability and degradation. USP7 antagonizes Mdm2, the E3 ligase for p53, thereby stabilizing p53 in response to oncogenic stress. It may function as a tumor suppressor by protecting p53 from degradation. USP7 also interacts with oncogenic pathways involving Myc and E1A, potentially providing an alternative mechanism for maintaining p53 stability independent of ARF.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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