Thermo Fisher Scientific NAGPA Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 86%

Target Information

Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network.
This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases.
Commonly known as uncovering enzyme (UCE), this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties, producing the recognition marker.
The encoded preproprotein is proteolytically processed by furin to generate the mature enzyme, a homotetramer of two disulfide-linked homodimers.
Mutations in this gene are associated with developmental stuttering in human patients.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.