Thermo Fisher Scientific LXR alpha Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1:500–1:3,000
• Referenced publications available upon request

Product Specifications

Product Specific Information

• Recommended positive controls: HepG2, Molt-4, Raji
• Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (100%), Pig (100%), Rabbit (100%), Chicken (100%), Bovine (100%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor exhibiting ligand-dependent transcriptional activation. Its interaction with retinoic acid receptor (RXR) converts RXR from a silent DNA-binding partner to an active ligand-binding subunit, mediating retinoid responses through LXRES target genes. LXRES are DR4-type response elements with direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides.
NR1H3 plays a key role in cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8, and functionally interacts with RORA in liver metabolism regulation.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일: PA5-28439_LXR_alpha_Q13133-1_Rabbit.svg, PA5-28439_LXR_alpha_Q13133-1_Rabbit_PDP.jpeg)