Thermo Fisher Scientific LXR alpha Polyclonal Antibody
Thermo Fisher Scientific의 LXR alpha Polyclonal Antibody는 인간 LXR-alpha 단백질을 인식하는 토끼 유래 폴리클로날 항체입니다. Western blot에 적합하며, 높은 특이성과 재현성을 제공합니다. 항원 친화 크로마토그래피로 정제되어 연구용으로 사용됩니다.
- 카탈로그번호
- PA528439
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): Tested dilution 1:500–1:3,000
- Referenced publications available upon request
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region within amino acids 379–447 of Human LXR-alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2545915 |
Product Specific Information
- Recommended positive controls: HepG2, Molt-4, Raji
- Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (100%), Pig (100%), Rabbit (100%), Chicken (100%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor exhibiting ligand-dependent transcriptional activation. Its interaction with retinoic acid receptor (RXR) converts RXR from a silent DNA-binding partner to an active ligand-binding subunit, mediating retinoid responses through LXRES target genes. LXRES are DR4-type response elements with direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides.
NR1H3 plays a key role in cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8, and functionally interacts with RORA in liver metabolism regulation.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-28439_LXR_alpha_Q13133-1_Rabbit.svg, PA5-28439_LXR_alpha_Q13133-1_Rabbit_PDP.jpeg)
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