Thermo Fisher Scientific SHKBP1 Polyclonal Antibody
Human SHKBP1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태이며, 안정적인 PBS/glycerol 버퍼에 보관. EGFR 신호 조절 연구에 적합한 연구용 시약.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SHKBP1. Recombinant protein control fragment (Product #RP-99113). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647279 |
Product Specific Information
Immunogen sequence:
PVFPVKRRNR HSLVGPQQLG GRPAPVRRSN TMPPNLGNAG LLGRMLDEKT PPSPSGQPEE PGMVRLVCGH HNWIAVAYTQ FLVCYRLKEA
Highest antigen sequence identity to the following orthologs:
- Mouse: 96%
- Rat: 94%
Target Information
Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1.
Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR-containing vesicles upon EGF stimulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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