ELK Biotechnology AXIN1 rabbit pAb
AXIN1 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 사용 가능. 인간, 마우스, 랫트에 반응하며 세포질, 핵, 세포막에서 발현. WNT 신호전달 경로의 음성 조절 연구에 적합.
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제품명
AXIN1 rabbit pAb
제품 설명
AXIN1 단백질을 인식하는 토끼 폴리클로날 항체입니다. WNT 신호전달 경로의 음성 조절자로 작용하는 AXIN1 단백질 연구에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 190–270) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 94 kDa |
| Gene ID (Human) | 8312 |
| Human Swiss-Prot No. | O15169 |
| Cellular Localization | Cytoplasm, Nucleus, Membrane, Cell membrane. MACF1 is required for its translocation to the cell membrane (By similarity). On UV irradiation, translocates to the nucleus and colocalizes with DAAX (PubMed:17210684). |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometrioid adenocarcinomas, and medulloblastomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
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