ELK Biotechnology ELOC rabbit pAb

제품명

ELOC rabbit pAb

제품 설명

ELOC 단백질(Elongin C)을 인식하는 토끼 다클론 항체입니다. RNA polymerase II 전사 신장 조절 복합체의 구성 요소로 알려진 ELOC 단백질의 검출에 사용됩니다. WB 및 ELISA 실험에 적합하며, 사람, 생쥐, 랫트 시료에서 반응합니다.

제품 정보

Background

This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B, and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, thereby inhibiting transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011]