ELK Biotechnology HJURP rabbit pAb
HJURP 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 인간, 랫, 마우스 시료에 반응하며, 핵과 염색체 중심체에 주로 위치합니다. CENPA 단백질의 조립과 유지에 중요한 역할을 연구하는 데 유용합니다.
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HJURP rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | HJURP rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 80–160) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 82 kD |
| Gene ID (Human) | 55355 |
| Human Swiss-Prot No. | Q8NCD3 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Nucleus, nucleolus, chromosome (centromere). Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, often related to storage. |
Background
Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Directly binds Holliday junctions.
Subcellular location: Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage.
Subunit: Interacts with CENPA (via CATD domain); the interaction is direct and specific for CENPA since it does not interact with H3.1- or H3.3-containing nucleosomes. Interacts with 14-3-3 family members in a phosphorylation-dependent manner. Interacts with MSH5 and NBN.
Tissue specificity:
According to PubMed:17256767, highly expressed in the thymus with lower levels in the placenta, small intestine, liver, skeletal muscle, and colon.
According to PubMed:17823411, highly expressed in testis, and at a relatively lower level in thymus and bone marrow. Significantly overexpressed in many lung cancer samples compared with normal lung.
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