ELK Biotechnology CP3A5 rabbit pAb
Cytochrome P450 계열의 효소 CP3A5를 인식하는 rabbit polyclonal antibody. WB 및 ELISA에 적합하며, 인간·쥐·마우스 시료에서 반응. 약물 대사 및 스테로이드 합성 연구에 활용 가능.
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제품 개요
제품명: CP3A5 rabbit pAb
공급업체: ELK Biotechnology
본 항체는 cytochrome P450 계열 효소 중 하나인 CP3A5 단백질을 인식하는 rabbit polyclonal antibody입니다. 약물 대사, 콜레스테롤 및 스테로이드 합성과 관련된 연구에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | CP3A5 rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB: 1:500–2000, ELISA: 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 200–280) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 55 kD |
| GeneID (Human) | 1577 |
| Human Swiss-Prot No. | P20815 |
| Cellular Localization | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone.
This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertension. Alternative splicing results in multiple transcript variants.
(Source: RefSeq, Apr 2014)
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