ELK Biotechnology CDA7L rabbit pAb
CDCA7L 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot과 ELISA에 사용 가능. 인간, 랫, 마우스에 반응하며 세포질 및 핵에서 발현되는 단백질 검출에 적합. -20°C에서 1년 보관 가능.
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제품명
CDCA7L rabbit pAb
제품 설명
CDCA7L 단백질을 인식하는 토끼 폴리클로날 항체입니다. 본 항체는 인간 유래 합성 펩타이드(AA 140–220)를 면역원으로 사용하였으며, 세포질과 핵에서 발현되는 CDCA7L 단백질 검출에 적합합니다. Western blot(WB) 및 ELISA 분석에 활용할 수 있습니다.
제품 사양
| 항목 | 내용 |
|---|---|
| Applications | WB; ELISA |
| Recommended Dilutions | WB: 1:500–1:2000 ELISA: 1:5000–1:20000 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 140–220) |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 49 kDa |
| Gene ID (Human) | 55536 |
| Human Swiss-Prot No. | Q96GN5 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Cytoplasm, Nucleus. Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction. |
| Storage | -20°C, 1 year |
Background
Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; may act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.
Induced by MYC overexpression in a concentration-dependent manner in neuroblastoma cell lines.
Cells lacking CDCA7L display a 25–30% reduction in colony formation in medulloblastoma cell lines, while CDCA7L overexpression induces colony formation.
Associates with chromatin and translocates from cytoplasm to nucleus under dexamethasone induction.
Interacts with MYC and PSIP1.
Ubiquitously expressed and overexpressed in medulloblastoma tissues.
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