Thermo Fisher Scientific CaV1.3 Polyclonal Antibody
Rabbit polyclonal antibody against human CaV1.3 (CACNA1D) for IHC and ICC applications. Recognizes recombinant human Calcium Channel 1D. High specificity and purity via antigen affinity chromatography. Supplied in PBS with 40% glycerol, 0.02% sodium az...
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Calcium Channel 1D. Recombinant protein control fragment (Product #RP-102095). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2639225 |
Product Specific Information
Immunogen sequence:
EDPEIHGYFR DPHCLGEQEY FSSEECYEDD SSPTWSRQNY GYYSRYPGRN IDSERPRGYH HPQGFLEDDD SPVCYDSRRS PRRRLLPPTP ASHRRSSFNF ECLRRQSSQE EVPSSPIFPH RTALPLHLMQ QQIMAV
Highest antigen sequence identity to the following orthologs:
- Mouse: 87%
- Rat: 85%
Target Information
CACNA1D (also known as PASNA, SANDD, or CaV1.3) encodes the alpha-1D subunit of the voltage-dependent calcium channel complex. These channels mediate calcium ion entry into excitable cells and participate in processes such as muscle contraction, neurotransmitter release, and gene expression.
Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The alpha-1 subunit forms the pore and determines channel properties, while the others act as auxiliary regulators. Multiple alpha-1 isoforms (A, B, C, D, E, S) confer distinct functional properties. Several transcript variants encoding different isoforms of CACNA1D have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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