Thermo Fisher Scientific PIAS3 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 452-628 of human PIAS3 (NP_006090.2). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PIAS3,uniProtId:Q9Y6X2-1,ncbiNodeId:9606,antigenRange:452-628,antigenLength:628,antigenImageFileName:PA5-110167_PIAS3_Q9Y6X2-1_Rabbit.svg,antigenImageFileNamePDP:PA5-110167_PIAS3_Q9Y6X2-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.76 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2855578

Product Specific Information

Immunogen sequence: IESSSDEEDL PPTKKHCSVT SAAIPALPGS KGVLTSGHQP SSVLRSPAMG TLGGDFLSSL PLHEYPPAFP LGADIQGLDL FSFLQTESQH YGPSVITSLD EQDALGHFFQ YRGTPSHFLG PLAPTLGSSH CSATPAPPPG RVSSIVAPGG ALREGHGGPL PSGPSLTGCR SDIISLD

Target Information

The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS3. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS3 binds specifically to STAT3 following the stimulation of STAT3. Increased expression of PIAS3 has been observed in several human cancers, including lung, breast, and brain tumors, but not in anaplastic lymphoma kinase-positive T/-cell lymphomas, indicating that PIAS3 plays multiple roles in different tissue and cell types.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.