Thermo Fisher Scientific PIAS3 Polyclonal Antibody
PIAS3 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot, IHC, ELISA에 사용 가능하며, 고순도의 Affinity Chromatography로 정제되었습니다. -20°C에서 보관하며 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 452–628 of human PIAS3 (NP_006090.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.76 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855578 |
Product Specific Information
Immunogen sequence:
IESSSDEEDL PPTKKHCSVT SAAIPALPGS KGVLTSGHQP SSVLRSPAMG TLGGDFLSSL PLHEYPPAFP LGADIQGLDL FSFLQTESQH YGPSVITSLD EQDALGHFFQ YRGTPSHFLG PLAPTLGSSH CSATPAPPPG RVSSIVAPGG ALREGHGGPL PSGPSLTGCR SDIISLD
Target Information
The PIAS (protein inhibitor of activated STAT) proteins are transcriptional coregulators involved in various cellular signaling pathways, including STAT, p53, and steroid hormone signaling. The PIAS family includes at least five conserved genes, including PIAS3. PIAS proteins regulate gene transcription and can act as SUMO E3 ligases. PIAS3 specifically binds to STAT3 following its activation. Overexpression of PIAS3 has been observed in several human cancers such as lung, breast, and brain tumors, but not in anaplastic lymphoma kinase-positive T-cell lymphomas, suggesting diverse roles in different tissues and cell types.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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