Thermo Fisher Scientific BCL9L Polyclonal Antibody
BCL9L 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 Immunoprecipitation에 사용 가능. 인간 BCL9L의 525–575번 잔기 영역을 면역원으로 제작. 액상 형태, 1 mg/mL 농도, 4°C 보관. 암 연구 및 Wnt 신호전달 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 525 and 575 of human B-Cell CLL/Lymphoma 9-Like |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
Bcl9L, a homolog of Bcl9, was initially identified through bioinformatics screening. It is expressed in fetal brain, adult lung, eye, and prostate, as well as in several tumor types including pancreatic and prostate cancers.
Bcl9L interacts with beta-catenin, a target of the Wnt signaling pathway, and is required for enhanced beta-catenin–TCF-mediated transcription in colorectal tumor cells, possibly by translocating beta-catenin to the nucleus.
Studies suggest that Bcl9L expression correlates with high nuclear grade cancer phenotype and ErbB2/HER-2 expression in breast cancers, indicating a potential role in other cancer types.
Bcl9L is also critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas, associated with tumor invasion, metastasis, and therapy resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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