Thermo Fisher Scientific SRC Recombinant Rabbit Monoclonal Antibody (23GB1110)
SRC 단백질을 인식하는 재조합 토끼 단일클론 항체로, Western blot, ICC/IF, Flow Cytometry에 적합합니다. 고순도 친화 크로마토그래피 정제, 0.2 mg/mL 농도, HEK293F 발현 시스템 사용. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB1110 |
| Immunogen | Synthetic peptide of human Src (29–44AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
SRC is a cytoplasmic tyrosine kinase and proto-oncogene involved in the regulation of embryonic development and cell growth. It regulates growth and differentiation of eukaryotic cells, associates with cytoplasmic regions of various cell surface receptors to facilitate signal transduction, and contributes to cytoskeletal organization, cell cycle regulation, and apoptosis.
In humans, SRC is encoded on chromosome 20. Its activity is regulated by phosphorylation of two tyrosine residues (Tyr416 and Tyr527), which exert opposing effects: phosphorylation of Tyr416 activates SRC, while phosphorylation of Tyr527 inhibits it. Mutations in SRC may be associated with malignant progression of colon cancer. Two transcript variants encoding the same SRC protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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