Thermo Fisher Scientific CLEC7A/Dectin-1 (extracellular) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Reconstitution: 25 µL, 50 µL, or 0.2 mL double distilled water (DDW), depending on sample size.
• Ships as a lyophilized powder at room temperature.
• Upon arrival, store at -20°C.
• Reconstituted solution can be stored at 4°C for up to 1 week.
• For longer storage, aliquot and store at -20°C.
• Avoid multiple freeze/thaw cycles.
• Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

CLEC7A, also known as Dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells.
It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain and a cytoplasmic domain containing an immunoreceptor tyrosine-based activation motif (ITAM).
CLEC7A functions as a pattern-recognition receptor that recognizes beta-1,3- and beta-1,6-linked glucans from fungi and plants, playing a key role in innate immune response.
Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering an oxidative burst through reactive oxygen species formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.