Thermo Fisher Scientific S1P1 Monoclonal Antibody (8E4H5)
S1P1 단백질을 표적으로 하는 마우스 단일클론 항체. Western blot, IHC, Flow cytometry, ELISA에 적합. 인체 시료 반응성 확인. 단백질 G 정제 및 PBS 완충액에 보존. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8E4H5 |
| Immunogen | Purified recombinant fragment of human CD363 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898397 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
S1P1 is a G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that is coupled to the G(i) subclass of heteromeric G proteins.
S1P1 signaling leads to the activation of RAC1, SRC, PTK2/FAK1, and MAP kinases. It plays a critical role in cell migration through actin cytoskeleton reorganization and lamellipodia formation in response to sphingosine kinase SPHK1 activity.
S1P1 is essential for normal chemotaxis toward S1P, embryonic heart development, and cardiac morphogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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