Thermo Fisher Scientific Ku80 Monoclonal Antibody (9403)
Ku80 단백질을 인식하는 Mouse Monoclonal Antibody로 Western blot 및 Immunocytochemistry에 최적화됨. 인간 및 비인간 영장류 반응성. Recombinant N-terminal Ku80 항원으로 제작되어 DNA 복구 연구에 적합. 단백질 G 정제, 1 mg/mL 농도, PBS 용액 형태.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:5,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 9403 |
| Immunogen | Recombinant antigen containing the amino terminal portion of human Ku80 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_561982 |
Product Specific Information
- Recommended positive controls: T24, Jurkat, Raji, 293T, A431, HeLa, HepG2, H1299, HCT116, MCF-7, NT2D1, PC-3, U87-MG
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein, also known as ATP-dependent DNA helicase II or DNA repair protein XRCC5.
Ku is the DNA-binding component of the DNA-dependent protein kinase and functions together with the DNA ligase IV–XRCC4 complex in the repair of DNA double-strand breaks by non-homologous end joining and completion of V(D)J recombination events.
This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and V(D)J recombination.
A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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