Thermo Fisher Scientific ZNF496 Monoclonal Antibody (4B1)
ZNF496 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체(4B1). Western blot, ICC/IF, ELISA에 사용 가능하며, 인간 시료에 반응. 비결합형 액상 형태로 제공되며, PBS(pH 7.4)에 보존제 없이 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 0.3 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4B1 |
| Immunogen | ZNF496 (NP_116141, 485–585 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein:
HLQPDRLQPV EKREQAASED ADKGPKEPLE NGKAKLSFQC CECGKAFQRH DHLARHRSHF HLKDKARPFQ CRYCVKSFTQ NYDLLRHERL HMKRRSKQAL NTarget Information
ZNF496 contains a SCAN box, a KRAB-A domain, and four consensus C2H2-type zinc fingers preceded by a unique finger derivative (C2HR motif).
The C2HR motif mediates protein-protein interaction with the cysteine-rich (C5HCH) domain of NSD1 in a Zn(II)-dependent manner.
When tethered to RNA polymerase II promoters, it represses transcription in an NSD1-dependent fashion.
ZNF496 contains a novel type of zinc finger motif that functions as a docking site for NSD1 and is more than just a degenerate evolutionary remnant of a C2H2 motif.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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