Thermo Fisher Scientific JMJD1C Polyclonal Antibody
JMJD1C 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, IHC 및 IHC(P) 실험에 적합합니다. 인간 반응성, 토끼 IgG 호스트이며 항원 친화 크로마토그래피로 정제되었습니다. 4°C 보관, 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific JMJD1C Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 150 and 200 of human Jumonji Domain Containing 1C |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on sequence identity, predicted to react with Bovine, Panda, Orangutan, Gorilla, Chimpanzee, Northern white-cheeked gibbon, Small-eared galago, and Ferret
Target Information
The Jumonji domain containing 1C protein (JMJD1C) was initially discovered in silico and later suggested to be a candidate gene for autism.
Like JMJD1A and JMJD1B, JMJD1C is a histone H3K9 demethylase involved in nuclear hormone receptor-based transcriptional regulation.
JMJD1C mRNA is highly expressed in undifferentiated embryonic stem cells, pancreatic islet, diffuse-type gastric cancer, and various tissues and tumors.
Its promoter contains bHLH-, AP-1-, and POU5F1-binding sites, suggesting POU5F1-mediated expression may reactivate silenced genes in ES cells and diffuse-type gastric cancer.
At least three isoforms of JMJD1C are known to exist.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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