Thermo Fisher Scientific APP Monoclonal Antibody (OTI1E6), TrueMAB
인간 APP 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Luminex 등 다양한 면역분석에 적합. TrueMAB 포맷으로 높은 특이성과 재현성 제공. 연구용으로만 사용 가능하며, 알츠하이머 및 신경퇴행성 질환 연구에 활용 가능.
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Applications
- Luminex (LUM): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E6 |
| Immunogen | Full length human recombinant protein of human APP produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with <5% trehalose |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Additional Formats
Target Information
Amyloid Precursor Protein (APP), also known as Amyloid beta precursor protein, functions as a cell surface kinesin I membrane receptor mediating axonal transport of beta-secretase and presenilin 1. APP is crucial for neurite growth, neuronal adhesion, and axonogenesis. It is a 100–140 kDa transmembrane glycoprotein with several isoforms resulting from alternative splicing. Proteolytic cleavage by beta- and gamma-secretases generates beta amyloid, the main component of senile plaques—one of the major histopathologic features of Alzheimer’s disease. Abnormal APP regulation and processing are implicated in Down’s syndrome, early-onset familial Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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