Thermo Fisher Scientific Acetyl-p53 (Lys381) Polyclonal Antibody
인간, 마우스, 랫트에서 반응하는 Acetyl-p53 (Lys381) 폴리클로날 항체로, p53이 Lys381에서 아세틸화된 상태에서만 내인성 수준을 검출합니다. Western blot 및 IHC(파라핀) 적용 가능하며, 고순도 친화 크로마토그래피 정제 및 안정적인 PBS/glycerol 저장 버퍼를 사용합니다.
- 판매단위
- pk
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Thermo Fisher Scientific Acetyl-p53 (Lys381) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TP53 (Accession P04637), corresponding to amino acid residues L369–G389 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816583 |
Product Specific Information
Antibody detects endogenous levels of Acetyl-p53 only when acetylated at Lys381.
Target Information
The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nutrient deprivation. p53 up-regulation activates transcription of genes such as p21waf1, leading to G1 or G2/M arrest. Structurally, p53 contains:
- N-terminal transactivation domain
- Central DNA-binding domain
- Oligomerisation domain
- C-terminal regulatory domain
Phosphorylation at Ser15 is critical for activation and stabilization, while Ser392 phosphorylation is associated with tumor formation. p53 also plays roles in aging, oxidative stress, and memory function (LTP). Mutations in TP53 are common in human cancers and lead to loss of tumor suppressor activity. Germline mutations are found in cancer-prone families such as Li-Fraumeni syndrome.
Usage Restrictions
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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