Thermo Fisher Scientific PARP12 Polyclonal Antibody
Human PARP12 단백질을 인식하는 Rabbit Polyclonal Antibody. Western blot에 최적화되어 있으며, 합성 펩타이드(C-terminal, aa 224-273)를 면역원으로 사용. Affinity Chromatography로 정제된 0.5 mg/mL 액상 제품으로, -20°C 보관 권장.
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Applications
- Western Blot (WB): Tested dilution 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the C-terminal of human PARP12 (aa 224–273) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2605505 |
Product Specific Information
- Peptide sequence: PTIYRNAHDI KNKSSAPSRV PPLFVPQGTS ERKDSSGSVS PNTLSQEEGD
- Sequence homology:
- Dog: 100%
- Horse: 91%
- Human: 100%
- Rat: 100%
Target Information
Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) constitute a large family of 18 proteins encoded by different genes, displaying a conserved catalytic domain. PARP-1 (113 kDa) and PARP-2 (62 kDa) are the main enzymes whose catalytic activity is stimulated by DNA strand breaks. Novel PARP members extend the field of poly(ADP-ribosyl)ation to various aspects of cell biology, including cell proliferation and cell death. Some members share partners and subcellular localizations, suggesting fine regulation of this post-translational modification.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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