Thermo Fisher Scientific FBXW8 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Peptide sequence: MNQKLWEVYS GHPVQHISFS SHSLITANVP YQTVMRNADL DSFTTHRRHR
• Sequence homology:
  Cow: 83%
  Dog: 92%
  Guinea Pig: 83%
  Horse: 92%
  Human: 100%
  Mouse: 92%
  Rabbit: 100%
  Rat: 92%

Target Information

This gene encodes a member of the F-box protein family, characterized by an approximately 40 amino acid motif called the F-box.
F-box proteins form one of the four subunits of the ubiquitin protein ligase complex SCFs (SKP1-cullin-F-box), functioning in phosphorylation-dependent ubiquitination.
They are divided into three classes:

• Fbws: Containing WD-40 domains
• Fbls: Containing leucine-rich repeats
• Fbxs: Containing other protein-protein interaction modules or no recognizable motifs

The encoded protein contains both a WD-40 domain and an F-box motif, classifying it as a member of the Fbw class.
Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.