Thermo Fisher Scientific Phospho-Insulin Receptor Beta (Tyr1355) Polyclonal Antibody
인슐린 수용체 베타(Tyr1355) 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC, Flow, ELISA 등 다양한 응용에 적합합니다. Human, Mouse, Rat에 반응하며, Protein A로 정제된 액상 형태입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human Insulin Receptor beta around the phosphorylation site of Tyr1355 [RS(p-Y)EE] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through phosphorylation cascades. Binding of insulin or IGF-1 to their receptors induces autophosphorylation and activation of downstream targets. Although structurally related, these receptors differ in ligand specificity and intracellular signaling domains, leading to distinct biological outcomes. Defects in the insulin receptor (IR) are associated with insulin resistance syndromes, while IGF-1 receptor (IGF-1R) alterations may cause growth retardation. Both pathways are also implicated in cancer development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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