Thermo Fisher Scientific CPI-17 Polyclonal Antibody
CPI-17 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human 시료에 반응합니다. ICC/IF에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS(glycerol 포함) 용액 형태로 제공되며, 연구용으로 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PPP1R14A. Recombinant protein control fragment (Product #RP-106550) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2791358 |
Product Specific Information
Immunogen sequence:
GLLKSCGKPV EDFIQELLAK LQGLHRQPGL RQPSPSHDGS LS
Target Information
CPI-17 is a phosphorylation-dependent inhibitory protein for smooth muscle myosin phosphate. It was originally identified as a PKC-potentiated inhibitory protein of protein phosphatase-1, dominantly expressed in smooth muscle.
Phosphorylation at Threonine 38 by PKC or Rho-kinase enhances inhibitory potency toward myosin phosphatase. CPI-17 is also phosphorylated at Threonine 38 by protein kinase N and may be involved in calcium sensitization of smooth muscle contraction as a downstream effector of Rho and/or arachidonic acid.
It is dually phosphorylated at Serine 12 and Threonine 38 by a MYPT-associated kinase, M110 kinase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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