Thermo Fisher Scientific T-bet Polyclonal Antibody
T-bet(TBX21) 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC 등 다양한 응용에 사용 가능. Human, Mouse, Rat 시료에 적합하며, 0.5 mg/mL 농도의 액상 형태로 제공. 면역조절 및 자가면역 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.2–1 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | 5 µg/mL | View 3 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | – | View 2 publications |
| Surface Plasmon Resonance (SPR) | Assay-dependent | – |
Product Specifications
| Specification | Description |
|---|---|
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human TBX21 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2576589 |
Product Specific Information
- Peptide sequence: SIPSPPGPNC QFLGGDHYSP LLPNQYPVPS RFYPDLPGQA KDVVPQAYWL
- Sequence homology:
- Cow: 100%
- Dog: 100%
- Guinea Pig: 86%
- Human: 100%
- Mouse: 93%
- Pig: 100%
- Rabbit: 86%
- Rat: 86%
Target Information
T-bet (also known as TBX21) is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It regulates the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are essential in immune regulation and autoimmune disease development.
T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation toward Th1 rather than Th17. It cooperates with Stat4 (signal transducer and activator of transcription 4) to program chromatin architecture for Th1 gene expression.
Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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