Thermo Fisher Scientific NLRP3 Polyclonal Antibody
인간 NLRP3 단백질을 인식하는 Rabbit Polyclonal Antibody로, 면역세포 내 염증 반응 연구에 적합합니다. ICC/IF에 사용 가능하며, 보존제가 포함되지 않은 고순도 항체입니다. 단기 4°C, 장기 -20°C 보관 권장.
- 카탈로그번호
- PA580857
- 판매단위
- pk
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:300–1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the C-terminus of the Human Nlrp3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2788124 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human Nlrp3.
Target Information
The NLRP3 gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site domain, and a leucine-rich repeat motif.
This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, forming part of the NALP3 inflammasome complex.
The complex functions as an upstream activator of NF-kappaB signaling and plays a role in inflammation, immune response, and apoptosis.
Mutations in this gene are associated with familial cold autoinflammatory syndrome and neonatal-onset multisystem inflammatory disease.
Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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