Thermo Fisher Scientific Mouse SCF Recombinant Protein

Applications

Western Blot (WB)

• Assay-dependent

ELISA

• Assay-dependent

Control (Ctrl)

• Assay-dependent

Product Specifications

Product Specific Information

• Carrier-Free
• Stock solutions can also be prepared at 50–100 µg/mL in appropriate sterile buffer.
• Carrier protein such as 0.2–1% BSA or HSA can be added when preparing the stock solution.

Target Information

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression induces mast cell survival and the release of histamine, pro-inflammatory cytokines, and chemokines. Inhibition of the SCF/c-Kit pathway decreases histamine levels, mast cell and eosinophil infiltration, IL-4 production, and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.