Thermo Fisher Scientific ELL Polyclonal Antibody
ELL 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 Immunocytochemistry에 적합합니다. 인간 및 마우스 시료 반응성이 있으며, 고순도 친화 크로마토그래피 정제 제품입니다. 액상 형태로 −20°C 보관 권장.
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Applications
- Western Blot (WB): 1:500–1:1,000
- Immunocytochemistry (ICC/IF): 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ELL (Accession P55199), corresponding to amino acid residues E105–Y155 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850577 |
Product Specific Information
This antibody detects endogenous levels of total ELL.
Target Information
ELL is an elongation factor component of the super elongation complex (SEC), which enhances the catalytic rate of RNA polymerase II transcription by suppressing transient pausing at multiple DNA sites.
It is also a component of the little elongation complex (LEC), required for regulating small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780).
ELL specifically stimulates the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription and plays an early role in stabilizing RNA polymerase II recruitment and initiation prior to SEC assembly.
Required for stabilization of the pre-initiation complex and early elongation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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