Thermo Fisher Scientific Bcl-2 Monoclonal Antibody (100), FITC

Applications

• Flow Cytometry (Assay-Dependent)

Product Specifications

Additional Formats

• PE conjugate (MHBCL04)
• Custom conjugation available

Product Specific Information

FITC conjugates provide high absorptivity, excellent fluorescence quantum yield, and good water solubility, making them suitable for flow cytometry and fluorescence-based assays.

Target Information

BCL-2 is a key regulator of apoptosis, functioning to inhibit or promote cell death. Members of the BCL-2 family form dimers to modulate apoptosis.

• Bag1 forms a heterodimer with BCL-2, enhancing its anti-apoptotic effect.
• Bax and Bak promote cytochrome c release from mitochondria to initiate apoptosis.
• Overexpression of BCL-2, such as through translocation to the Ig heavy chain locus, is associated with follicular lymphoma and other cancers.
  Two transcript variants of BCL-2 differ in their C-terminal ends, and high levels of BCL-2 alpha protein are typically found in neoplastic germinal centers of follicular lymphomas.

Classification

Analyte Specific Reagent

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