Thermo Fisher Scientific CaV1.1 Polyclonal Antibody
CaV1.1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC(P) 실험에 적합합니다. Human에 반응하며 Mouse, Rat 등에서도 예측 반응성을 보입니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 544–885 of CACNA1S (Uniprot ID: Q13698) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.67 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at −20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11154016 |
Product Specific Information
- Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji
- Predicted reactivity: Mouse (93%), Rat (95%), Cat (95%), Rabbit (94%), Chicken (90%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Voltage-sensitive calcium channels mediate calcium entry into excitable cells and play a key role in neurotransmitter release and excitation-contraction (E-C) coupling.
The 1,4-dihydropyridines (DHPs) identify L-type calcium channels found in vertebrate muscle, neuronal, and neuroendocrine cells.
The DHP receptor, part of the L-type calcium channel complex, acts as the voltage sensor in E-C coupling and is composed of at least four subunits.
The alpha-1 subunit binds DHPs and shows high sequence homology to voltage-gated sodium channels.
The alpha-2 subunit is a large glycoprotein found in skeletal and cardiac muscle, brain, and other excitable tissues.
Additional beta and gamma subunits co-purify with the DHP receptor.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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